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Gondkar, S. B.
- Formulation and Evaluation of Mucoadhesive Buccal Patch of Saxagliptin Hydrochloride
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Authors
Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 8, No 4 (2016), Pagination: 237-247Abstract
Buccal route offers the advantage of avoiding first pass metabolism. Saxagliptin Hydrochloride in conventional dosage form is extensively metabolized by the liver. The Saxagliptin Hydrochloride is antidiabetic agent used in the treatment of type-II Diabetes mellitus. The oral bioavailability is 67%. The half-life of saxagliptin Hydrochloride is 2.5 hours and it undergoes hepatic metabolism. So, in order to improve the bioavailability and efficacy, we have prepared buccal patches of saxagliptin Hydrochloride. HPMC is one the polymers which is having good mucoadhesive property so therefore various formulations were developed by using release rate controlling HPMC K100M and Eudragit RL-100 by Solvent Casting technique. In addition to this propylene glycol - 400 was used as plasticizer and permeation enhancer respectively. Drug-excipients interaction study was proven if any. Buccal patches were characterized for number of parameters like Mechanical properties and , weight uniformity, thickness, Percent moisture loss, folding endurance, swelling index, surface pH, drug content uniformity, in-vitro residence time, drug-excipients interaction study, Mucoadhesive strength and in-vitro drug release study. 32 full factorial design was employed to study the effect of independent variables. The response of design was analyzed using Design Expert® trial version 7.0.0; and the tools of the software were used to draw Contour plot and 3D plot. On the basis of the software analysis, formulation F7 was selected as optimized formulation and evaluated for independent parameters. Optimized formulation showed 98.35 ± 0.52% dug release upto 6 hrs. Optimized formulation fulfils all necessary attributes required for Buccal Patch and can become a promising alternative to present marketed tablet of Saxagliptin Hydrochloride.Keywords
Buccal Patches, Saxagliptin Hydrochloride (SXG HCL), Hydroxypropylmethyl Cellulose (HPMC), and Eudragit RL-100.- An Overview on Sustain Release Matrix Drug Delivery System
Abstract Views :196 |
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Authors
Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 8, No 2 (2016), Pagination: 154-160Abstract
The oral route is the most frequently used route for the administration of drugs. Many of the pharmaceutical dosage form are formulated as sustained release dosage form to retard the release of a therapeutic agent such that its appearance in the systemic circulation is prolonged and its plasma profile is sustained in duration. Tablets offer the lowest cost approach to sustained and controlled release dosage forms. Matrix tablets serves as an important tool for oral extended- release dosage forms. Hence, problems like patient compliance, drug targeting, local side effects, frequent administration and fluctuations in blood concentration levels. Conventional drug delivery systems are known to provide a prompt release of drug or immediate release drug product. Such immediate release products result in relatively rapid drug absorption and onset of accompanying pharmacodynamic effects. Hence, change in the operation is a suitable and optimized way to make the some drug more effective by slight alteration in the drug delivery. Pharmaceutical industries and academic laboratories have been focused on development of novel drug delivery system or modified release dosage form rather investigation and development of new drug. Advance in technology have resulted in novel modified release dosage form. In contrast to conventional form, modified release products provide either delayed release or extended release of drug.Keywords
Hydrophilic and Hydrophobic Polymers, Matrix Tablet, Sustained Release Matrix Type Drug Delivery.- Nanocrystal Drug Delivery System:A Review
Abstract Views :206 |
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Authors
Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik, 422003, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik, 422003, IN
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik, 422003, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik, 422003, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 8, No 2 (2016), Pagination: 122-126Abstract
Nanotechnology is the science in which the particle having the size below 1000nm.Theimportance of nanotechnology in drug delivery is in the concept and ability to manipulate molecules and supramolecular structures for producing devices with programmed functions. One of the major application areas of nanotechnology in pharmacy is nanoparticular drug delivery system. Preparation of nanocrystals to improve the solubility of poorly water- soluble drug for oral delivery is also one of the important applications. Drug nanocrystals are crystals with a size in the nanometre nanoparticle with a crystalline character .The use of drug Nanocrystals is an universal formulation approach to increase the therapeutic performance of these drugs in any rout of administration.Keywords
Nanocrystal, Top Down, Bottom Up, Application.- In- Situ Nasal Gel: A Review
Abstract Views :162 |
PDF Views:1
Authors
Affiliations
1 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjenari, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjenari, Nashik-422213, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, R.G.Sapkal College of Pharmacy, Anjenari, Nashik-422213, Maharashtra, IN
1 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjenari, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjenari, Nashik-422213, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, R.G.Sapkal College of Pharmacy, Anjenari, Nashik-422213, Maharashtra, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 7, No 4 (2015), Pagination: 285-293Abstract
Nasal therapy also called "Nasya Karma" has been recognized form of treatment in the Ayurvedic. System of Indian Medicine. Nowadays many drugs have better systemic bioavailability through nasal route as compared to oral administration. The nose is also considered an attractive route for needle-free vaccination and for systemic drug delivery, especially when rapid absorption and effect are desired. The nasal delivery is a feasible alternative to oral or parenteral administration for some drug because of the high permeability of the nasal epithelium, rapid drug absorption across this membrane and avidance of first pass metabolism. Prolonged drug delivery can be achieved by various new dosage forms like in-situ gel. In-situ forming polymeric formulation are drug delivery system that is in sol form before administration in the body, but once administered, undergoes gelation in-situ to form a gel. In-situ nasal drug delivery system is the type of mucoadhesive drug delivery system. Now a days insitu gel has been used as vehicle for the drug delivery of the drug for both local treatment and systemic effect. In-situ nasal gel drug delivery system is advantageous over the conventional drug delivery system like sustained and prolonged release of drug, reduced frequency of administration, improved patient compliance and comfort.Keywords
Nasal Drug Delivery, Nasal In-Situ Gel, Mucoadhesive Drug Delivery System.- Formulation Development of Ketoconazole Ophthalmic Formulation
Abstract Views :232 |
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Authors
Affiliations
1 Department of Quality Assurance Techniques, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Quality Assurance Techniques, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN